Flint Minett has keratoconus, an eye disease, but desperately wants to win a comic book art contest so that he and his new friend McKell Panganiban will be better accepted at middle school.

Crusty dragon Miss Drake's new pet human, precocious ten-year-old Winnie, not only thinks Miss Drake is her pet, she accidentally brings to life her "sketchlings" of mysterious and fantastic creatures hidden in San Francisco, causing mayhem among its residents.

After Marvin, a beetle, makes a miniature drawing as an eleventh birthday gift for James, a human with whom he shares a house, the two new friends work together to help recover a Durer drawing stolen from the Metropolitan Museum of Art.